University of Havana

报告人简介：

Prof. Roberto Mulet works at the Center for Complex Systems and at the Department of Theoretical Physics of the University of Havana. His research work is concentrated on Statistical Physics, Soft Matter, Biological Physics, Nonlinear Dynamics and Theoretical Physics. He is currently serving as the president of the Physical Society of Cuba.

报告摘要：

I will show results obtained during the last few years merging techniques from Systems Biology and Bioinformatics to model Metabolic Networks. We will first introduce a theoretical model that justifies the presence of bistable states in a Toy model of metabolism and in mammalian cells. We will also present experimental results supporting these results. Then, we will show how to use the same mathematical framework to optimize in-silico the media used to grow mammalian cells in batch cultures and again we will report an experimental validation of our predictions. Finally, we demonstrate that the same idea can be extended to study heterogeneous cellular cultures and to estimate the distribution of flux densities of the chemical reactions in the metabolism.

地点：中国科学院物理研究所M楼236会议室

邀请人：陆颖（8264 8122）

联系人：胡颖（8264 9361）